Suggested guidelines for determining the trough-to-peak ratio of antihypertensive drugs

Reproducibility and Clinical Value of the Trough-to-Peak Ratio of the Antihypertensive Effect

The objectives of our study were to assess the reproducibility of the trough-to-peak ratio (T/P) and to see whether a high T/P is accompanied by more organ protection or vice versa. The study included 175 (mean6SD age, 5169 years) subjects with mild-moderate essential hypertension who had echocardiographic evidence of left ventricular (LV) hypertrophy taken from the SAMPLE study (Study on Ambul...

Reproducibility and clinical value of the trough-to-peak ratio of the antihypertensive effect: evidence from the sample study.

The objectives of our study were to assess the reproducibility of the trough-to-peak ratio (T/P) and to see whether a high T/P is accompanied by more organ protection or vice versa. The study included 175 (mean+/-SD age, 51+/-9 years) subjects with mild-moderate essential hypertension who had echocardiographic evidence of left ventricular (LV) hypertrophy taken from the SAMPLE study (Study on A...

THE EFFECT OF ANTIHYPERTENSIVE DRUGS IN THE SUPPRESSION OF ATHEROSCLEROSIS

The present investigation was undertaken to evaluate the effect of antihypertensive drugs on aortic atherogenesis in hypercholesterolemic rabbits. In enalapril and nifedipine treated rabbits aortic atherosclerotic plaque involvement was significantly decreased (p<0. Oland p<O. 05, respectively) as compared to the control group. However, in hydrochlorothiazide treated rabbits aortic atheroge...

Peak and Trough.

Dclcri~liiliilg lllc Trough-to-Peak Ratio in Parallel-Group Trials

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